February 3, 2013 / BIOON / --In the latest issue of Nature Chemical Biology, researchers from the University of Luxembourg, the Catholic University of Leuven, and the University of Florida described a new metabolic mechanism, named For metabolite damage-control, the researchers stated that they have provided an in-depth explanation of the metabolite damage and its repair or replacement, and the researchers also discussed the unnecessary small cells in the article. Molecules and related control mechanisms, and discusses the importance of cell quality control for cell function and body health.
Researcher Carole Linster said that the damage control of metabolites is a new concept, which transfers our concept from a linear metabolic pathway of high-efficiency enzymes to a more complex metabolic network. The repair response was considered. The researchers hope that their results can bring about changes in the cell's metabolism.
The molecules that make up living cells will continue to respond to damage and continue to deal with these damages, which is essential for the health and survival of the cell. Since the beginning of life, cell damage control has also emerged, and the repair mechanism of the cell It is also continuously renewed according to the evolution of life.
In recent years, many scientists have focused on the damage repair mechanism of large molecules such as DNA or proteins, while neglecting small molecules, such as metabolites, is your repair. The researchers explained that classic biochemistry tells us that as long as the enzyme is given an efficient substrate specificity, the metabolic reaction will proceed efficiently, but the cell will continue to produce damaged metabolites during the metabolic process, so the cell will have to Remove or repair these damaged metabolites. The loss of a metabolite repair mechanism will cause an individual's fatal disease.
At present, the research field of "metabolism damage control" is still in its infancy, and many biochemical researchers are also preparing to start studying and understanding the mechanism of cell repair damage metabolites, which means that there will be many cell metabolite damage repair systems in the future. be found. Researcher Linster said, I hope that the scientists who saw this article affirmed our research results and determined that the repair of metabolites is an important aspect of cell metabolism. This will encourage us to study in depth to find more mechanisms to improve our metabolism of cells. Understanding of product damage control and its importance. (Bioon.com)
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