Zhu Yingjie team invented a new preparation method, successfully prepared hydroxyapatite long fibers, and prepared these new hydroxyapatite refractory papers with these seemingly like noodles as the building material of the paper.
Zhu Yingjie (right rear) instructs students to do experiments in the laboratory.
"Under the drive of interest, various innovation inspirations will come to the fore." Zhu Yingjie, a researcher at the Shanghai Institute of Ceramics of the Chinese Academy of Sciences (hereinafter referred to as Shanghai Silicate Institute), said in an interview with the Journal of the Chinese Academy of Sciences. .
Take their recent research results for refractory paper, the main component of hydroxyapatite is originally the main inorganic component of vertebrate hard tissue bones and teeth. It is usually used in the biomedical field, and few people use it to make paper. Connected.
Zhu Yingjie believes that this is an inspiration from innovation.
Inspiration for innovation
In the face of the reporter's question, Zhu Yingjie can always give a very "conventional" answer, just like his daily "two-point work - go home and work" in general, not over the moment.
In fact, scientists are the most unconventional type of people. Most of them like to challenge new problems. In the experiment, they verify the new findings over and over again, and find more perfect answers again and again. Zhu Yingjie is such a "contradictory individual."
In 2002, Zhu Yingjie was elected to the "Hundred Talents Program" of the Chinese Academy of Sciences and returned to China from overseas. His team is mainly engaged in the research of nano-biomaterials. For 12 years, he and his team have achieved innovative results in the field of microwave-assisted rapid synthesis of nanomaterials, nanocrystal self-assembly and nano-biomaterials. At the beginning of this year, the refractory paper they developed again attracted countless attention and praise.
Since 2008, the synthesis of hydroxyapatite nanomaterials with various morphologies and their application in biomedicine has become a major research direction of Zhu Yingjie's team. After several years of hard work, they successfully synthesized hydroxyapatite fibers.
How is this fiber used in papermaking? Hydroxyapatite has excellent biocompatibility and is environmentally friendly. It exhibits high quality white, and more importantly, it does not burn and can withstand high temperatures. An ideal material.
But the idea is that if you want to make paper from hydroxyapatite, you have to overcome many other characteristics. For example, hydroxyapatite ceramics generally have high brittleness and low toughness.
How to improve the flexibility of hydroxyapatite materials has become the biggest challenge facing them. “We think that using hydroxyapatite fiber as a building material for paper has the potential to solve the problem of flexibility,†he said.
But the challenge is still coming. Hydroxyapatite is usually easy to form a rod or sheet shape during the synthesis process. How do you make it into a fiber?
Zhu Yingjie team invented a new preparation method, successfully prepared hydroxyapatite long fibers, and prepared these new hydroxyapatite refractory papers with these seemingly like noodles as the building material of the paper.
This refractory paper is highly flexible and can be arbitrarily crimped. The most amazing thing is that it does not burn and can be applied to writing and printing documents and files that require long-term preservation. As a permanent and secure information storage medium, it has a good application prospect.
“In the development of refractory paper, our inspiration for solving all the problems stems from the accumulation of daily research work, innovative thinking and hard work.†Zhu Yingjie said.
Scientific research can not be neglected
"As a scientific research worker, the most memorable moment of the emergence of new scientific research results." Zhu Yingjie said.
In addition to refractory paper, Zhu Yingjie team is still engaged in the research of nano-biomaterials. Calcium silicate is one of the biological materials, mainly used for bone tissue repair. In fact, they have been studying the use of calcium silicate in drug loading and release since 2008.
When investigating drug loading, they found that the prepared calcium silicate hydrate porous microspheres formed by nanosheet self-assembly had an ultra-high ibuprofen drug loading.
"We felt that this was a bit unbelievable, because this situation has not been found in other material systems." Zhu Yingjie said. After trial and error, they confirmed the results of this experiment - the drug loading of porous microspheres exceeded the highest reported in all literature.
At the same time, they also discovered for the first time that the porous microspheres of calcium silicate hydrate have different drug release rules from other material systems reported in the literature - the drug release amount is linear with the natural logarithm of the release time. Prior to this, other drug-loaded systems reported in the literature showed a linear relationship between the drug release and the square root of the release time.
"Of course, the discovery process of this innovative result is very tortuous and difficult." Zhu Yingjie said.
Drug release is a long process. In order to obtain accurate and reasonable experimental results, overnight experiments are often required to obtain relatively continuous test points. Sometimes, a little neglect of the experimental design and operation process will lead to the elimination of the entire experiment.
Hard work pays off. In the end, their research results were published in the international authoritative journal Advanced Materials and obtained a Chinese invention patent license.
Rely on the power of the team
In the research work, in addition to carrying out a large number of experiments every day, Zhu Yingjie will leave enough time to summarize, read the literature and think. "I require team members to have sufficient experimental plans, clear experimental purposes, carefully and carefully during the course of the experiment, paying particular attention to the observation of the details of the experiment, detailing the experimental process and phenomena, and summarizing and analyzing the results of the day."
Innovation is not a shot taken, it is a gradual process. In the meantime, all kinds of difficulties will always come out from time to time. At this time, “reliant on the team's innovative thinking†is particularly important.
In 2008, Zhu Yingjie led the team to develop the "new calcium phosphate-block copolymer composite nano-gene carrier and its application in the treatment of lung cancer." This is a Shanghai-based project funded by nano-specialization. The research involves many interdisciplinary subjects including chemistry, materials science, biology and medicine. The research is very difficult and puts very high demands on the research team.
At that time, the research direction of Zhu Yingjie's team had just been transferred to the field of calcium phosphate nanomaterials. The foundation was relatively weak, and the relevant biological and medical research conditions were very limited.
What to do? Cooperation! They found Shanghai Jiaotong University and Shanghai Cancer Research Institute. They read a lot of literature, invested a lot of time to work overtime to solve technical problems, and obtained innovative research results, and completed the project brilliantly.
In the past ten years, Zhu Yingjie has carried out extensive research and development in the development of new methods for rapid, low-cost, energy-saving and environmentally friendly microwave synthesis of nanomaterials, and has achieved a series of innovative research results. They have also developed a variety of new methods for microwave synthesis, and applied these methods to the rapid preparation of a variety of nanomaterials and the morphology control of nanostructures.
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