Recently, a research paper "T cell differentiation factor CBF-β regulates HIV Vif protein to escape host defense system" written by Chinese scientists and technicians was published in the British "Nature" magazine. Related research will open up new directions for adding new members of AIDS cocktail therapy, which is of great significance to AIDS treatment.
The results were obtained by the scientific research team of the Institute of AIDS and Virus, Bethune First Hospital of Jida University and Johns Hopkins University in the United States, led by Professor Yu Xiaofang of Jilin University.
The results show that “CBF-β†is a cytokine that can interact with HIV infection factor “Vif†in the human body. If "CBF-β" does not exist, then the natural anti-viral mechanism in the human body can inhibit the HIV virus, and the virus will not be able to complete the replication.
According to the evaluation of academic experts, the discovery revealed and improved the mechanism of action of HIV V protein to overcome the host defense system, and discovered and defined the important regulatory role of T cell differentiation factor CBF-β in the host cell during virus invasion and replication The invention of new anti-AIDS inhibitors provides a theoretical basis, which will help humanity finally overcome and overcome AIDS.
Yu Xiaofang has been devoted to the research of viral molecular pathogenic mechanism for more than 20 years. In 1988, he first discovered and identified Vpx and Vpr as functional genes of HIV. In 2003, he firstly revealed the interaction mechanism between HIV Vif protein and host defense factors in the American "Science" magazine, which was widely cited by the academic circles. As a tenured professor at Johns Hopkins University, Yu Xiaofang returned to Jilin University in 2010 through the National "Thousand Talents Program" and took the lead in forming the Institute of AIDS and Virus Research at Jilin University.
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