Complete genome sequencing of brain cancer cell line was completed for the first time. Scientists from the University of California, Los Angeles, Jonson Comprehensive Cancer Research Center published a paper in the special issue of "PLoS Genetics" on January 29th. The whole genome sequencing of the brain cancer cell line has been performed, which is the most thorough sequencing analysis to date for a single cancer cell line. By using the latest technology, this sequencing work can be completed within a month, and the cost of sequencing is about 35,000 US dollars. The research results are a new step towards personalized treatment based on the unique biological signature of a single cancer, and the new molecular targets it reveals will help develop more potent and less toxic drugs. This research will also be of great help to better find new methods for monitoring the recurrence of brain cancer, so that doctors can diagnose and treat the recurrence of brain cancer earlier. With this discovery, clinicians can also determine the exact time when brain cancer cells are inactivated to prevent damage to human health caused by excessive use of drugs. The sequencing work was done on a glioblastoma cell line called U87, and more than 1,000 laboratories around the world are using the U87 cell line for research. The cell line was chosen because it is currently the most well-studied. This sequencing work will enable scientists engaged in cell line research to re-explain their research findings and prompt them to propose new directions. The sequencing work revealed almost all potential carcinogenic chromosomal translocations and gene deletions and mutations that led to the development of the cancer. The researchers took the long chain of genetic material from the cell line and then randomly truncated it. The billions of different DNA fragments of this cancer can be read simultaneously by next-generation sequencing technology, and the genetic material can be analyzed with more than 1 billion times to ensure high sensitivity and accuracy. The researchers said that this special information tool uses the most advanced technology at present, which will greatly improve the effectiveness of genetic analysis. Previously, scientists could not understand most of the mutations that occurred in a cancer because they were invisible. Now, this new technology will allow scientists to monitor every cancer and completely decode its genome, so scientists You wo n’t miss any cancer-causing mutation. Knowing which genes are mutated and driving the development of cancer, clinicians can choose the most suitable therapy to attack specific molecular signatures of cancer, thereby providing patients with more effective treatment. The sequencing work can also reveal the molecular abnormalities that drive the development of cancer, and the revealed targets may help to develop new therapies that only attack cancer cells without harming healthy cells. The researchers also pointed out that with the cancer gene sequencing map, scientists can develop sensitive molecular detectors to find a unique genetic mutation that can only be found in cancer cells. As long as this mutation is detected, it can be determined that the cancer has recurred, so that the patient can be actively treated at the earliest stage of cancer recurrence. In turn, this detection method can also be used to determine whether the cancer has been effectively eliminated, thereby promptly stopping the treatment of harmful human bodies.
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